Braga 4-0 Ferencváros (0-2 en la ida)
11′ Horta (Braga), 15′ Grillitsch (Braga), 34′ Martínez (Braga), 53′ Horta (Braga)
Lyon vs Celta Vigo 0-2 (1-1 en la ida)
61′ Rueda (C), 90+2′ Jutgla (C)
Freiburgo 5-2 Genk (0-1 en la ida)
19′ Ginter (F), 25′ Matanović (F), 39′ Smets (G), 53′ Grifo (F), 56′ Suzuki (F), 79′ Eggestein (F)
Midtjylland vs Nottingham Forest 1-2 (0-3 en penaltis) (ida 1-0)
40′ Domínguez (N), 52′ Yates (N), 69′ Erlic (M)
Aston Villa vs Lille 2-0 (ida 1-0)
54′ McGinn (A), 86′ Bailey (A)
Betis vs Panathinaikos 4-0
8′ Ruibal (B), 45′ Amrabat (B), 53′ Hernández (B), 66′ Antony (B)
Porto vs Stuttgart 2-0
21′ Gomes (P), 72′ Froholdt (P)
Roma vs Bologna 3-4 (ida 1-1)
22′ Rowe (B), 32′ Ndicka (R), 45+2′ penalti Bernardeschi (B), 58′ Castro (B), 68′ penalti Malen (R), 80′ Pellegrini (R), 111′ Cambiaghi (B)
